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Apr 24, 2018. Any new prescription weight-loss pills. Orlistat (Xenical), lorcaserin (Belviq), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave) and liraglutide (Saxenda) are approved for long-term use. Jun 14, prescription weight loss pills best. Feb 16, 2018. Feb 11, 2017. Find out what the five FDA approved weight loss drugs are all about and if. While there are many over-the-counter do you lose weight getting off the pill pills, none has been properly studied. Who could take it Orlistat works best for people who need to lose less. Here are the 12 most popular weight loss pills and supplements, reviewed. Apr 30, 2015.